Central serous chorioretinopathy

The pathogenesis of central serous chorioretinopathy (CSC) is still not fully understood. The involvement of corticosteroids is undisputed, although their exact role has not been clarified; other parts of the underlying mechanism of CSC have been mainly elucidated by imaging techniques such as fluorescein and indocyanine green angiography. Even though most cases of CSC are self-limiting, severe as well as recurrent courses exist, and for these patients only a limited number of treatment options are available: laser photocoagulation, with a risk of scotoma and choroidal neovascularization, and photodynamic therapy. In this review article, we give an overview of its epidemiology, the current understanding of its pathogenesis as well as systemic and ocular risk factors. We illuminate modern diagnostic tools as well as current treatment options in the context of CSC, particularly in the light of a better understanding of corticosteroids and their receptors involved in its pathogenesis

Ethically aware IT design for emergency response:from co-design to ELSI co-design

The latest EU funding framework, ‘Horizon 2020’, has moved consideration of ethical and societal implications of technology development to the fore. Yet, there is little guidance on how to do such research in practice, let alone how to innovate in ethically and socially sound ways. This paper addresses these issues in the context of a large scale EU funded project developing system of system innovations in IT supported emergency response. Building on collaborative design and a range of other approaches, the paper argues that just like ‘usability’, ethics cannot be invented or decided by experts, but has to be the product of engagement with the technology by directly or indirectly implicated publics. Facilitating such publics is a central element of what we call ‘ELSI Co-Design’. The paper outlines the theoretical and methodological underpinnings of this approach

Don’t drone?:negotiating ethics of RPAS in emergency response

This paper explores discourses of automation as a key ethical concern in the development of Remotely Piloted Aircraft Systems for disaster response. We discuss problems arising from ‘humanistic’ dichotomies that pit human against machine, military against civil uses and experts against laypersons. We explore how it may be possible to overcome human-technology dichotomies

Was hat Geschlecht mit Raum und Zeit zu tun?

Alltäglich denken wir weder über Geschlecht noch Raum noch Zeit groß nach, wir gehen allerdings ständig damit um - in eingeübten Verhaltensmustern. Auch ohne darüber nachzudenken, sind wir daran gewöhnt, Raum und Zeit miteinander zu verknüpfen: Wenn wir eine Verabredung treffen, legen wir dafür einen Ort und einen Termin fest. Vergäßen wir das eine oder das andere, käme ein Treffen kaum zustande. Ähnlich sind wir daran gewöhnt, dass Landschaften zu bestimmten Jahreszeiten ein anderes Aussehen annehmen oder dass Menschen im Laufe ihres Lebens sowohl den Anspruch ans Wohnen als auch die Ausgestaltung ihrer Wohnung ändern - jedes Lebensalter hat also ein eigenes räumliches Gesicht. Etwas schwieriger erscheint die Verknüpfung von Geschlecht mit Raum oder von Geschlecht mit Zeit oder erst recht von Geschlecht mit RaumZeit. Unsere Art der Problematisierung des Themenfeldes 'Geschlecht und RaumZeit' beruht auf der Annahme, dass sowohl die Gegenstände wissenschaftlicher Betrachtungen als auch die Gegenstände dominanter Alltagsauseinandersetzungen abhängig sind von ihrer historischen Einbettung, politischen und ökonomischen Möglichkeiten sowie soziokulturellen Entwicklungen. Im wissenschaftlichen Diskurs wird diesbezüglich von sozialer Konstruktion gesprochen. Wenn Geschlecht wie Raum wie Zeit als sozial konstruiert angenommen werden und damit gesellschaftlichem Wandel unterliegen, ist auszuführen, von welchem Verständnis von Geschlecht und von RaumZeit ausgegangen werden kann. Erst auf Grundlage solchen Vorverständnisses kann eine Materialauswahl und Materialzusammenstellung für Lehrveranstaltungen zum Themenfeld vorgenommen werden

Sorafenib prevents human retinal pigment epithelium cells from light-induced overexpression of VEGF, PDGF and PlGF

Background Cumulative light exposure is significantly associated with progression of age-related macular degeneration (AMD). Inhibition of vascular endothelial growth factor is the main target of current antiangiogenic treatment strategies in AMD. However, other growth factors, such as platelet-derived growth factor (PDGF) and placenta growth factor (PlGF), have a substantial impact on development of AMD. Previous reports indicate that sorafenib, an oral multikinase inhibitor, might have beneficial effects on exudative AMD. This study investigates the effects of sorafenib on light-induced overexpression of growth factors in human retinal pigment epithelial (RPE) cells. Methods Primary human RPE cells were exposed to white light and incubated with sorafenib. Viability, expression, and secretion of VEGF-A, PDGF-BB, and PlGF and their mRNA were determined by reverse transcription-polymerase chain reactions, immunohistochemistry and enzyme-linked immunosorbent assays. Results Light exposure decreased cell viability and increased expression and secretion of VEGF-A, PDGF-BB and PlGF. These light-induced effects were significantly reduced when cells were treated with sorafenib at a dose of 1 mu g/ml. Conclusion The results show that sorafenib has promising properties as a potential antiangiogenic treatment for AMD

Designing for ethical innovation:a case study on ELSI co-design in emergency

The ever more pervasive ‘informationalization’ of crisis management and response brings both unprecedented opportunities and challenges. Recent years have seen the emergence of attention to ethical, legal and social issues (ELSI) in the field of Information and Communication Technology. However, disclosing (and addressing) ELSI issues in design is still a challenge because they are inherently relational, arising from interactions between people, the material and design of the artifact, and the context. In this article, we discuss approaches for addressing such ‘deeper’ and ‘wider’ political implications, values and ethical, legal and social implications that arise between practices, people and technology. Based on a case study from the BRIDGE project, which has provided the opportunity for deep engagement with these issues through the concrete exploration and experimentation with technologically augmented practices of emergency response, we present insights from our interdisciplinary work aiming to make design and innovation projects ELSI-aware. Crucially, we have seen in our study a need for a shift from privacy by design towards designing for privacy, collaboration, trust, accessibility, ownership, transparency etc., acknowledging that these are emergent practices that we cannot control by design, but rather that we can help to design for—calling for approaches that allow to make ELSI issues explicit and addressable in design-time

Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45

Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates potentially combining antigenic and adjuvant properties in one substance. To more precisely characterize the potential of Escherichia coli OMV for intranasal vaccination with heterologous antigens, immune responses for AnAPN1 and Pfs48/45 as well as ovalbumin as a reference antigen were assessed in mice. The intranasal adjuvant cholera toxin (CT) and parenteral adjuvant MF59C.1 were used in comparison. Vaccinations were administered intranasally or subcutaneously. Antibodies (total IgG and IgM as well as subclasses IgG1, IgG2a, IgG2b, and IgG3) were measured by ELISA. T cell responses (cytotoxic T cells, Th1, Th17, and regulatory T cells) were determined by flow cytometry. When OMV were used as adjuvant for intranasal immunization, antibody and cellular responses against all three antigens could be induced, comparable to cholera toxin and MF59C.1. Antigen-specific IgG titres above 1 : 10 5 could be detected in all groups. This study provides the rationale for further development of OMV as a vaccination strategy in malaria and other diseases

Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45

Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates potentially combining antigenic and adjuvant properties in one substance. To more precisely characterize the potential of Escherichia coli OMV for intranasal vaccination with heterologous antigens, immune responses for AnAPN1 and Pfs48/45 as well as ovalbumin as a reference antigen were assessed in mice. The intranasal adjuvant cholera toxin (CT) and parenteral adjuvant MF59C.1 were used in comparison. Vaccinations were administered intranasally or subcutaneously. Antibodies (total IgG and IgM as well as subclasses IgG1, IgG2a, IgG2b, and IgG3) were measured by ELISA. T cell responses (cytotoxic T cells, Th1, Th17, and regulatory T cells) were determined by flow cytometry. When OMV were used as adjuvant for intranasal immunization, antibody and cellular responses against all three antigens could be induced, comparable to cholera toxin and MF59C.1. Antigen-specific IgG titres above 1 : 10 5 could be detected in all groups. This study provides the rationale for further development of OMV as a vaccination strategy in malaria and other diseases

Comparative Evaluation of Combined Navigated Laser Photocoagulation and Intravitreal Ranibizumab in the Treatment of Diabetic Macular Edema

Objective: To evaluate if a standardized combination therapy regimen, utilizing 3 monthly ranibizumab injections followed by navigated laser photocoagulation, reduces the number of total ranibizumab injections required for treatment of diabetic macular edema (DME). Research Design and Methods: A 12-month, prospective comparison of 66 patients with center-involving DME: 34 patients with combination therapy were compared to 32 patients treated with ranibizumab monotherapy. All patients initially received 3 monthly ranibizumab injections (loading phase) and additional injections pro re nata (PRN). Combination therapy patients additionally received navigated laser photocoagulation after the loading phase. Main outcome measures were mean number of injections after the loading phase and change in BCVA from baseline to month 12. Results: Navigated laser combination therapy and ranibizumab monotherapy similarly improved mean BCVA letter score (+8.41 vs. +6.31 letters, p=0.258). In the combination group significantly less injections were required after the 3 injection loading phase (0.88 +/- 1.23 vs. 3.88 +/- 2.32, p<=0.001). By month 12, 84% of patients in the monotherapy group had required additional ranibizumab injections as compared to 35% in the combination group (p<=0.001). Conclusions: Navigated laser combination therapy demonstrated significant visual gains in most patients. Retreatment rate and number of injections were significantly lower compared to ranibizumab monotherapy and compared to the results of conventional laser combination therapy previously reported in pivotal anti-VEGF studies

Managing Visibility and Validity of Distress Calls with an Ad-Hoc SOS System

The availability of ICT services can be severely disrupted in the aftermath of disasters. Ad-hoc assemblages of communication technology have the potential to bridge such breakdowns. This article investigates the use of an ad-hoc system for sending SOS signals in a large-scale exercise that simulated a terrorist attack. In this context, we found that the sensitivity that was introduced by the adversarial nature of the situation posed unexpected challenges for our approach, as giving away one's location in the immediate danger of a terrorist attack became an issue both for first responders and the affected people in the area. We show how practices of calling for help and reacting to help calls can be affected by such a system and affect the management of the visibility and validity of SOS calls, implying a need for further negotiation in situations where communication is sensitive and technically restrained